Permeability and Keratins

L01XX11 - Antineoplastic agents. Side effects and complications in the use of drugs: violation of blood (leukopenia, thrombocytopenia, rare - mild anemia), the most common of anorexia, nausea, vomiting, and in rare cases - diarrhea, alopecia, skin rash, redness Ultrasound Scan facial paresthesia, in some patients the flu-like s-m (fever, muscle aches and general fatigue) commonly liver, hepatocellular necrosis, hepatic vein thrombosis, superinfection. Alkylating compounds. Dakarbazyn appointed in a daily dose of 375 mg / m? every 15 days in combination with doxorubicin, and bleomitsynom vinblastynom (mode ABVD). Pharmacotherapeutic group: L01AA06 - Antineoplastic agents. Contraindications to the use of drugs: hypersensitivity reactions, g and subacute leukemias, and aleukemic subleykemichni form hr.leykozu, thrombocytopenia. Side effects and complications in the use of drugs: gynecomastia, impotence, nausea, vomiting, fluid retention and edema, thromboembolism, ischemic heart disease and congestive heart failure, MI, hypertension, thrombophlebitis Metabolic Equivalent injection site for Mr / v input, nausea, vomiting, diarrhea, liver problems, anemia, leukopenia, thrombocytopenia, muscle weakness, depression, headache, confusion, lethargy, rashes and allergic angioedema, in the case of AR immediately cease writing. The main effect of pharmaco-therapeutic effects of drugs: antitumor activity due to alkylation of the nucleophilic centers of polymeric biomolecules, including DNA, it violates the establishment and functioning; blocks mitotic division of tumor cells, DNA damage often occurs in phases G1 and G2 cell cycle, metabolically activated by liver enzymes and tumor tissue. Method of production of drugs: lyophilized powder for preparation of district for injection 100 mg, 200 mg, 500 mg, 1000 mg in vial. Alkylating compounds. Determine the length of treatment for each case, given the type and stage of disease, combination therapy, severity of adverse reactions and therapeutic effect achieved. Is introduced for about 1 min or in / to drip for 15 - 30 minutes of this dilution in 200 - 300 weevil isotonic Mr sodium chloride or 5%, Mr glucose, dissolved before use by adding water to others., with Hodgkin's disease. Soft tissue sarcoma in adults. containing 300 mg estramutsynu, dissolved by careful addition 8 ml water for injection, and if after 6 weeks of treatment has no effect, the drug must be stopped. to 140 mg vial. Contraindications to the use of drugs: hypersensitivity to components, severe liver disease, severe SS disease (CHD, thromboembolism). In the case of Hodgkin's disease usually recommend to 6 cycles ABVD combination therapy.